Defense
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| Addict | -5 | You're addicted to drugs... all of them. Take any status-effect-causing drug on a regular basis to avoid withdrawal effects. | |
| Banana Lover | 2 | Bananas give you 2X health | |
| Banana Lover + | 3 | Bananas give you 4X health | |
| Blaster Survivor | 3 | Explosions caused by the player, don't damage the player | |
| Block Bullets | 7 | Face the direction of incoming bullets to block them with your melee weapon | |
| Block Bullets + | 10 | Face the direction of incoming bullets to block them with your melee weapon | |
| Bloodlust | 16 | Killing people restores your health | |
| Bloodlust + | 16 | Killing people restores your health | |
| Bodyguard | -9 | You are responsible for the well-being of an extremely important Musician who will follow you everywhere, and probably not cause any trouble whatsoever | |
| Bullet Sponge | 7 | Bullets cause less damage and knockback | |
| Bullet Sponge + | 10 | Bullets cause less damage and knockback | |
| Diminutive | -4 | Short stature means you take more damage and inflict less damage, and can fit down toilets | |
| Disturbing Facial Expressions | 3 | Enemies are more likely to run away during battle | |
| Disturbing Facial Expressions + | 5 | Enemies are more likely to run away during battle | |
| Electronic | -3 | Status effects usually don't affect you, you can't eat food, and you're damaged by water and EMP blasts | |
| Fireproof Skin | 3 | Fire damage decreased | |
| Fireproof Skin + | 5 | Fire damage decreased | |
| Flesh Feast | 5 | Hitting non-neutralized opponents with your melee attacks restore health | |
| Flesh Feast + | 7 | Hitting non-neutralized opponents with your melee attacks restore health | |
| I'm Outtie | 7 | Gain speed when health is low | |
| I'm Outtie + | 10 | Gain speed when health is low | |
| Jugularious | -4 | Blood is the only thing that can restore your health | |
| Longer Status Effects | 3 | Status effects inflicted on you last longer | |
| Longer Status Effects + | 5 | Status effects inflicted on you last longer | |
| Medical Professional | 3 | Each follower's health can be restored once per floor. Can use Blood Bag | |
| Modern Warfarer | 5 | Health gradually regenerates when below 20 | |
| Modern Warfarer + | 7 | Health gradually regenerates when below 40 | |
| Oil Reliant | -4 | Health can be restored by Oil Container or Ammo Dispenser | |
| Prickly Skin | 5 | Melee damage inflicted on the player may also harm the attacker | |
| Prickly Skin + | 7 | Melee damage inflicted on the player may also harm the attacker | |
| Safe in Crowds | 3 | The more nearby followers you have, the less damage you take. Caps at 3 followers. | |
| Safe in Crowds + | 5 | The more nearby followers you have, the less damage you take. Caps at 3 followers. | |
| Slippery Target | 3 | Enemies have more difficulty aiming at you | |
| Slippery Target + | 5 | Enemies have more difficulty aiming at you | |
| Un-Crits | 5 | Damage inflicted on the player may not cause any health loss | |
| Un-Crits + | 7 | Damage inflicted on the player may not cause any health loss |